Charles and Ray married in 1941 and moved to California where they continued their furniture design work with moulding plywood. During the war, they were commissioned by the Navy to produce moulded plywood splints, stretchers and experimental glider shells. In 1946, Evans Products began producing the Eameses' moulded plywood furniture.

Their moulded plywood chair was called "the chair of the century" by the influential architectural critic Esther McCoy. Soon production was taken over by Herman Miller, who continues to produce the furniture in the United States to this day.

In 1949, Charles and Ray designed and built their own home in Pacific Palisades, California as part of the Case Study House Program sponsored by Arts and Architecture Magazine. Their design and innovative use of materials made this house a mecca for architects and designers from all over the world. It is considered one of the most important post-war residences built anywhere in the world.